Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,726 – 4,740 of 60,549 results

4,726

Medchemexpress LLC Betrixaban maleate | 936539-80-9 | MFCD31729381 | 99.8% | 567.98 g/mol | C27H26ClN5O7 | 25 MG

Betrixaban maleate is the maleate salt of betrixaban, a potent and selective orally active factor Xa (fXa) inhibitor used as a research compound to study coagulation and antithrombotic pharmacology. The compound is supplied as a high-purity research chemical suitable for in vitro and in vivo experiments.

High purity suitable for research (99.78%).
Maleate salt improves handling and solubility properties.
Targets factor Xa for antithrombotic studies.
Molecular weight 567.98 g/mol; formula C27H26ClN5O7.
Available in small milligram quantities for laboratory use (e.g., 25 mg).
Supplied for research use only; not for human or clinical applications.

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4,727

Medchemexpress LLC Di-n-butyl phthalate-d22 | 358731-15-4 | MFCD01861629 | 99.0% | 300.48 g·mol⁻¹ | C16D22O4 | 1mg

Dibutyl phthalate-d22 is the deuterium labeled Dibutyl phthalate[1] Dibutyl phthalate is a commonly used plasticizer commonly found in some food packaging materials personal care products and the coating of oral medications May cause toxicity and adverse neurobehavioral effects[2][3][4]

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4,728

Cayman Chemical BODIPY 493/503, Purity: ≥98%, CAS: 121207-31-6, 5 mg

A fluorescent probe for lipid droplets; can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells; compatible with epifluorescent, confocal, and two-photon microscopy, as well as flow cytometry; ex/em = 493/503 nm

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4,729

Medchemexpress LLC BMS-986235 (LAR-1219) | 2253947-47-4 | 99.7% | 500 MG

BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure.

It inhibits neutrophil chemotaxis and stimulates macrophage phagocytosis, key endpoints to promote resolution of inflammation.
It can attenuate left ventricle and global cardiac remodeling after left anterior descending (LAD) in mice (0.3 mg/kg; p.o.; daily for 24 days).
Treatment shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours, 120 nmol/L·h, and 24%, respectively (1 mg/kg; p.o.).

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4,730

Cayman Chemical GSK2193874, Purity: ≥95%, CAS: 1336960-13-4, 5 mg

A potent, selective antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC50 values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively; effective in vivo, as it resolves pulmonary edema resulting from myocardial infarction in mice

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4,731

Cayman Chemical JPH203, Purity: ≥98%, CAS: 1037592-40-7, 1 mg

An inhibitor of LAT1 (IC50 = 0.14 μM for 14C-leucine uptake in S2 cells expressing the human transporter); selective for LAT1 over LAT2 (IC50 = >10 μM); inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 μM, respectively); induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and PARP in YD-38 oral cancer cells at 3 mM; reduces tumor growth in an HT-29 mouse xenograft model at 6.3, 12.5, and 25 mg/kg

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4,732

Cayman Chemical Falcarinol, Purity: ≥60%, CAS: 21852-80-2, 5 mg

A plant defense polyacetylene; inhibits fatty acid biosynthesis in pathogens; binds to hCB1 and hCB2 receptors (Kis = 594 and 2,100 nM, respectively); modulates synaptic and extrasynaptic GABAA receptors; inhibits ATPase activity in ABCG2 (IC50 = 79.3 μM); inhibits aberrant crypt foci (26.6%) in azoxymethane-induced rats

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4,733

Medchemexpress LLC Muramyl dipeptide (MDP) | 53678-77-6 | 99.1% | 10 MG

Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide composed of N-acetyl muramic acid attached to an L-Ala-D-isoGln amino acid chain. It acts as an inducer of bone formation by promoting Runx2 and directly enhances osteoblast differentiation via MAPK pathways. MDP is also a NLRP1 agonist.

Synthetic immunoreactive peptide
Induces bone formation through induction of Runx2
Directly enhances osteoblast differentiation via MAPK pathways
Acts as a NLRP1 agonist
Increases protein expression of Runx2 in a dose-dependent manner
Increases mRNA levels of Runx2 in a dose-dependent manner
Indirectly attenuates osteoclast differentiation
Alleviates bone loss induced by osteoporosis in animal models
Significantly enhances trabecular bone volume and number in vivo

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4,734

Medchemexpress LLC Polyvinylpyrrolidone K25 | 9003-39-8 | 100MG

Polyvinylpyrrolidone K25 is a multifunctional synthetic polymer that serves as a versatile excipient for both conventional formulations and novel controlled or targeted delivery systems. It also functions as a preferable binder for granules and tablets. It prevents or retards drug crystallization from supersaturated systems by inhibiting nucleation and/or crystal growth, which allows for complete drug release.

Versatile excipient
Binder for granules and tablets
Inhibits drug crystallization
Allows complete drug release
Can be used as a coating agent
Functions as a suspending agent
Acts as a pore-former
Used as a solubilizer
Provides stabilization

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4,735

Cayman Chemical D-Ribulose, Purity: ≥95%, CAS: 488-84-6, 10 mg

A ketopentose synthesized in the pentose phosphate pathway that plays a role in the formation of various bioactive compounds

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4,736

Cayman Chemical Estrone 3-sulfate (sodium salt), Purity: ≥95%, CAS: 438-67-5, 5 mg

A steroid; selectively inhibits OATP1B1 over OATP1B3 (IC50s = 0.06 and 19.3 µM, respectively)

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4,737

TARGETMOL CHEMICALS INC SB-657510 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human monkey cat rat and mouse were 61 17 30 65 and 56 nM respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators such as adhesion molecules in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models. purity: 98%

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4,738

Cayman Chemical 2,5-DMMA, Purity: ≥98%, CAS: 54687-43-3, 10 mg

A designer drug that combines the 2,5 disubstitution pattern of 2,5-dimethoxyphenethylamines with the backbone of methamphetamine; intended for forensic and research applications

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4,739

Cayman Chemical GSK3179106, Purity: ≥98%, CAS: 1627856-64-7, 25 mg

An inhibitor of RET kinase (IC50 = 0.4 nM); selective for RET kinase over VEGFR2/KDR (IC50 = 109 nM); reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at 10 mg/kg twice per day

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4,740

Medchemexpress LLC EXP3179 10mM 1mL | 114798-36-6 | 420.89 | C22H21ClN6O | 1 ML

EXP3179 is an important intermediate aldehyde metabolite of Losartan EXP3179 has no AT1-R blocking activity but potently inhibits the expression of endothelial cyclooxygenase (COX)-2 EXP3179 exerts potent anti-inflammatory actions[1]

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Bioactive Small Molecules

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Medchemexpress LLC Betrixaban maleate | 936539-80-9 | MFCD31729381 | 99.8% | 567.98 g/mol | C27H26ClN5O7 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Di-n-butyl phthalate-d22 | 358731-15-4 | MFCD01861629 | 99.0% | 300.48 g·mol⁻¹ | C16D22O4 | 1mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BMS-986235 (LAR-1219) | 2253947-47-4 | 99.7% | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Muramyl dipeptide (MDP) | 53678-77-6 | 99.1% | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Polyvinylpyrrolidone K25 | 9003-39-8 | 100MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EXP3179 10mM 1mL | 114798-36-6 | 420.89 | C22H21ClN6O | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More