Bioactive Small Molecules
Medchemexpress LLC Plk4-in-1 | 1247001-12-2 | 99.8% | 431.23 | 5 MG
Plk4-in-1 is a Plk4 inhibitor with an IC50 of ≤ 0.1 μM. It is for research use only.
- Plk4 inhibitor
- IC50 of ≤ 0.1 μM (Plk4)
- High purity (99.84%)
Medchemexpress LLC AGX51 | 330834-54-3 | 99.3% | 431.52 | 5 MG
AGX51 is a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, primarily used in cancer research. It functions by inhibiting Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids. This action results in cell growth arrest and a reduction in cell viability, demonstrating an ability to inhibit Triple-Negative Breast Cancer (TNBC) with an IC50 of approximately 25 nM.
- First-in-class pan-Id antagonist and degrader
- Inhibits Id1-E47 interaction
- Leads to ubiquitin-mediated degradation of Ids
- Results in cell growth arrest and viability reduction
- Effective in inhibiting Triple-Negative Breast Cancer (TNBC)
Medchemexpress LLC Blu2864 | 2810747-89-6 | 99.5% | 452.43 | 50 MG
BLU2864 is an orally active, highly selective, and ATP-competitive PRKACA inhibitor with an IC50 of 0.3 nM. This compound demonstrates anti-tumor activity and is suitable for research related to cancer and polycystic kidney disease.
- Highly selective, ATP-competitive PRKACA inhibitor
- Exhibits anti-tumor activity
- Supports cancer research
- Supports polycystic kidney disease research
- Inhibits forskolin-induced in vitro cystogenesis
- Inhibits renal PKA activity
- Ameliorates polycystic kidney disease
- Reduces tumor growth in vivo
Medchemexpress LLC CP681301 | 865317-32-4 | 99.13% | 298.38 | 500 MG
CP681301 is a potent CDK5 inhibitor exhibiting antiproliferative activity. It effectively decreases the expression of CD133, OLIG2, SOX2, KI67, and pCDK5 protein levels in Glioma stem cells (GSCs). This compound also reduces self-renewal in mouse glioma xenografts and shows anti-tumor activity in Drosophila.
- Potent CDK5 inhibitor
- Shows antiproliferative activity
- Decreases expression of CD133, OLIG2, SOX2, KI67, and pCDK5 protein level in GSCs
- Reduces self-renewal in mouse glioma xenografts
- Demonstrates anti-tumor activity in Drosophila
- Variably cytotoxic effects on GSC cultures
- Not toxic to normal human neuro-progenitors (NHNPs)
- Suppresses CREB Ser133 phosphorylation expression
- Increases median survival in Drosophila models
Medchemexpress LLC Necrostatin-34 | 375835-43-1 | 98.9% | 384.48 | 5 MG
Necrostatin-34 is a RIPK1 kinase inhibitor that stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain. It is intended for research use only.
- RIPK1 kinase inhibitor
- Stabilizes RIPK1 kinase in an inactive conformation
- Occupies a distinct binding pocket in the kinase domain
- Inhibits dimerization-induced RIPK1 activation
- May block TNFα-induced complex II formation
Medchemexpress LLC STING agonist-26 | 2868261-48-5 | C40H49N15O5 | 25 MG
STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. It activates STING and increases phosphorylation of STING, TBK1, and IRF3.
- Promotes levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells.
- Exhibits activity against SARS-CoV series strains.
- Increases phosphorylated STING, TBK1, and IRF3 levels after 3 hours in THP-1 cells.
- Increases IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 levels after 5 hours in THP-1 cells.
- Induces strong antibody immune response when combined with SARS-CoV-2 RBD-Fc protein in a mouse model.
Medchemexpress LLC Estradiol 3-sulfate 17-glucuronide potassium salt | 10392-35-5 | 98.3% | 604.75 g/mol | C24H30K2O11S | 500UG
Estradiol 3-sulfate 17-glucuronide (dipotassium salt) (CAS 10392-35-5) is a conjugated metabolite of estradiol used in biochemical and pharmacological research, including studies of steroid metabolism and transporter interactions. The compound is supplied as a research-grade dipotassium salt with reported solubility in common organic solvents; confirm lot-specific purity and storage conditions from the certificate of analysis and SDS.
Medchemexpress LLC JNJ-47117096 hydrochloride | 1610536-69-0 | 99.7% | 398.89 g·mol⁻1 | C21H23ClN4O2 | 10MG
JNJ-47117096 hydrochloride is the hydrochloride salt of a potent and selective MELK inhibitor, with reported MELK IC50 = 23 nM and Flt3 IC50 = 18 nM. It is supplied as a high-purity research reagent for in vitro kinase profiling and cancer-signaling studies; not for human use.
- Potent MELK inhibition (IC50 = 23 nM).
- Secondary Flt3 activity (IC50 = 18 nM).
- Hydrochloride salt form for improved solubility and stability.
- High reported purity (≈99.7%).
- Suitable for in vitro kinase assays and cell signaling experiments.
- Intended for research use only.
Cayman Chemical TFlR-NH2trIfluoroacetate s 5mg
A peptide agonist of PAR1; induces calcium mobilization in isolated rat dorsal root ganglion neurons (EC50 = 1.9 μM); stimulates plasma extravasation in the bladder, esophagus, stomach, intestine, and pancreas in wild-type mice at 3 μmol/kg; reduces carrageenan-induced hyperalgesia in rats
Medchemexpress LLC Dota-(t-butyl)3-peg5-azide | 00-00-0 | 99.7% | 861.08 g/mol | C40H76N8O12 | 5 MG
DOTA-(t-butyl)3-PEG5-azide is a PEG-based linker containing a protected DOTA chelator and a terminal azide group. It is designed for bioconjugation and linker synthesis, enabling efficient coupling to alkyne-bearing partners via copper-catalyzed or strain-promoted azide-alkyne cycloaddition. The reagent offers a flexible spacer and high purity for reproducible coupling reactions.
Medchemexpress LLC PSB 0777 ammonium | >=97.0% | 500.55 | C18H24N6O7S2 | 5 MG
PSB 0777 ammonium is a potent, selective adenosine A2A receptor full agonist used as a research reagent to study A2A-mediated signaling and pharmacology. It is supplied in small quantities for laboratory use and has reported nanomolar activity in receptor binding assays.
- Potent and selective adenosine A2A receptor full agonist.
- Nanomolar binding activity to A2A receptors.
- Suitable for in vitro and in vivo research applications.
- Supplied in small quantity packages, typically 1 mg and 5 mg.
- Purity ≥97% (HPLC) as reported by independent suppliers.
- Chemical formula C18H24N6O7S2; molecular weight 500.55.
Cayman Chemical ANTIBODY Catlpol 50mg
An iridoid glycoside; has anti-apoptotic, pro-angiogenic, and radioprotective properties; protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells at a concentration of 10 µM; pretreatment at concentrations of 25-100 UG/ml reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation; reduces radiation-induced intestinal damage in mice pretreated at doses of 25-100 mg/kg, i.p.; improves angiogenesis in a rat model of stroke by increasing erythropoietin and VEGF expression in the brain at a dose of 5 mg/kg, i.p.
Cayman Chemical 4chloroN NDImethylcathInon 5mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical ANTIBODY ACT-709478 25mg
An inhibitor of T-type calcium channels (IC50s = 6.4, 18, and 7.5 nM for Cav3.1, Cav3.2, and Cav3.3, respectively); selective for T-type calcium channels over the L-type calcium channel Cav1.2 (IC50 = 2,410 nM); reduces the cumulative duration of absence-like seizures in rats at 10 mg/kg; reduces seizure severity in a rat model of audiogenic seizures at 100 mg/kg
Medchemexpress LLC YNT-185 dihydrochloride | 1804978-82-2 | 99.8% | 688.66 g/mol | C33H39Cl2N5O5S | 5 MG
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist supplied as the dihydrochloride salt for research use. It shows potent activity at OX2R with selectivity over OX1R and is intended for in vitro and in vivo pharmacology studies.
- Potent orexin type-2 receptor agonist (EC50 = 28 nM at human OX2; OX1 EC50 = 2.75 μM).
- High chemical purity: 99.78%.
- Characterized compound with CAS 1804978-82-2 and formula C33H39Cl2N5O5S.
- Provided as the dihydrochloride salt to aid handling and solubility.
- Available in milligram quantities and as a 10 mM solution in DMSO for convenience.
- Suitable for in vitro and in vivo orexin receptor pharmacology research.